鄭州大學(xué)化學(xué)與分子工程學(xué)院導(dǎo)師：于明明 正文

　
　　姓名：于明明　　性別：男　　職稱：副教授　　
　　學(xué)院：化學(xué)與分子工程學(xué)院　最后學(xué)歷：博士
　　電話：0371-67781205    電子郵件：
　　個人網(wǎng)址：
　　實(shí)驗(yàn)室：化學(xué)實(shí)驗(yàn)樓121 辦公室：化學(xué)實(shí)驗(yàn)樓118
　　通訊地址：鄭州大學(xué)化學(xué)系 450001

　　學(xué)歷教育：
　　● 吉林大學(xué)學(xué)士（1994），吉林大學(xué)碩士（1998）
　　● 中科院理化所博士（2002）
　　● 清華大學(xué)博士后（2005）

　　研究興趣：
　　生物熒光分子探針：過渡金屬及重金屬廣泛地存在于自然界中，其中的一些元素在生命過程中具有非常重要的功能，如已知銅在腫瘤血管生長因子中扮演非常重要的調(diào)節(jié)作用,鋅廣泛參與細(xì)胞生長發(fā)育、基因轉(zhuǎn)錄、神經(jīng)傳遞等各種重要生命過程；而另外一些元素則在很低濃度時就對生物具有極強(qiáng)的毒性,如鉛能引起消化系統(tǒng)、神經(jīng)系統(tǒng)及心臟的病變，汞對腎功能會引起嚴(yán)重?fù)p傷。因此，這些物質(zhì)的檢測對生命、環(huán)境和醫(yī)學(xué)科學(xué)以及工農(nóng)業(yè)生產(chǎn)等具有重要的意義。
　　課題研究具有高靈敏性、快速響應(yīng)、高空間分辨率的熒光分子探針，探討探針的識別機(jī)制，用無損傷細(xì)胞的方法測定細(xì)胞內(nèi)游離金屬的濃度，研究某種能夠通透細(xì)胞膜的金屬探針試劑，并在細(xì)胞內(nèi)與金屬離子發(fā)生作用等，可望用于細(xì)胞內(nèi)的分子熒光成像。
　　功能高分子材料、熒光高分子：研究特殊結(jié)構(gòu)高分子（超支化高分子、樹枝狀高分子、溫敏高分子、pH敏感高分子）的熒光響應(yīng)、能量傳遞、生物模擬以及高分子結(jié)構(gòu)與熒光相互作用的規(guī)律。這方面研究期望用于人造太陽能光收集、熒光離子捕獲、熒光染料以及生物標(biāo)記與藥物輸運(yùn)領(lǐng)域。

　　目前主持的研究課題：
　　● 國家自然科學(xué)基金“具有雙識別協(xié)同作用的鋅、銅離子熒光分子探針”（項目批準(zhǔn)號：50903075）
　　● 中國科學(xué)院光化學(xué)轉(zhuǎn)換與功能材料重點(diǎn)實(shí)驗(yàn)室開放課題“人造捕光天線的分子設(shè)計與應(yīng)用”

　　近期代表文章：
　　1. Zhanxian Li, Lifeng Zhang, Lina Wang, Yongkai Guo, Lianheng Cai, Mingming Yu,* Liuhe Wei* Highly Sensitive and Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Comm., 2011, published online. (c1cc10696a) (Impact Factor: 5.504)
　　2. Zhanxian Li, Mingming Yu,* Lifeng Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Comm., 2010, 46, 7169 - 7171. (Impact Factor: 5.504)
　　3. Ming Ming Yu, Xia Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157-1161.
　　4. Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A 1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of Zn2+ and Cu2+ Org. Lett., 2008, 22(10), 5115-5118. (Impact Factor: 5.420)
　　5. Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear Complexes with S=5 and S = 5 × 2 2 Ground State Eur. J. Inorg. Chem., 2007, 5670-5676. (Impact Factor: 2.9)
　　6. Zhan-Xian Li, Wen-Fu Fu, Ming-Ming Yu, Xi-Juan Zhao, Yong Chen The synthesis and properties of phenolic schiff bases based on 1,8-naphthyridine Dyes and Pigments, 2007, 75, 516-520. (Impact Factor: 2.855)

　　專利：
　　于明明，李占先，魏英耐，魏柳荷，石秋芝“一種鋅、銅離子熒光探針及其制備方法與應(yīng)用”專利公開號：CN101446547
　　李占先，于明明，張利鋒，虞明，魏柳荷，劉金霞“一種檢測細(xì)胞內(nèi)鋅離子的分子熒光開關(guān)及其應(yīng)用”專利公開號：CN101914375

　　Experience:
　　Department of Chemistry, Zhengzhou University, Zhengzhou, 2007-present
　　Department of Chemistry, Tsinghua University, Beijing, 2005-2007: Post Doctor
　　Technical Institute of Physics and Chemistry of CAS, Beijing, 2002-2005: Ph. D.
　　Jilin University, Changchun Jilin, 1998-2001: MS
　　Jilin University, Changchun Jilin, 1994-1998: BS
　　
　　Research Areas:
　　Fluorescent molecules
　　Functional polymers
　　Grant Support:
　　National Science Foundation of China, Synergy with Dual Recognition of Zinc, Copper Ion Fluorescence Molecular Probe (Grant no. 50903075), 2010-2013.
　　Open fundation of Key Laboratory of Photochemical Conversion and Optoelectronic Materials，TIPC，CAS
　　
　　Papers:
　　Huiqiang Li, Zhanxian Li, Linzhi Wu, Fang Liu, Jie Zhou, Miao Luan, Mingming Yu*, Liuhe Wei* Water-Soluble Starlike Poly(acrylic acid) Graft Polymer: Preparation and Application as Templates for Silver Nanoclusters polymer bulletin, accepted.
　　Zhanxian Li*, Lifeng Zhang, Xiaoya Li, Yongkai Guo, Zhonghai Ni, Jianhong Chen, Liuhe Wei, Mingming Yu* A fluorescent color/intensity changed chemosensor for Fe3+ by photo-induced electron transfer (PET) inhibition of fluoranthene derivative Dyes and Pigments, accepted.
　　Zhanxian Li, Wanying Zhao, Yuna Zhang, Lifeng Zhang, Mingming Yu*, Jinxia Liu* and Hongyan Zhang* An “off-on” fluorescent chemosensor of selectivity to Cr3+ and its application to MCF-7 cells Tetrahedron, 2011, 67, 7096 - 7100.
　　Zhan-Xian Li, Li-Feng Zhang, Wan-Ying Zhao, Xiao-Ya Li, Yong-Kai Guo, Ming-Ming Yu*, Jin-Xia Liu* Fluoranthene-based pyridine as fluorescent chemosensor for Fe3+ Inorg. Chem. Commun., 2011, 14, 1656 - 1658.
　　Zhanxian Li, Lifeng Zhang, Lina Wang, Yongkai Guo, Lianheng Cai, Mingming Yu,* Liuhe Wei* Highly Sensitive and Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Comm., 2011, 47, 5798 – 5800.
　　Zhanxian Li, Mingming Yu,* Lifeng Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Comm., 2010, 46, 7169 - 7171.
　　Ming Ming Yu, Xia Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157-1161.
　　Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A 1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of Zn2+ and Cu2+ Org. Lett., 2008, 22(10), 5115-5118.
　　Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear Complexes with S=5 and S = 5 × 2 Ground State Eur. J. Inorg. Chem., 2007, 5670-5676.
　　YU Ming-Ming, KOU Hui-Zhong, ZHAO Chong-Chao, ZHENG Lei, CUI Ai-Li Synthesis and crystal structure of two coordination compounds CuLClOH and Ni(L)2 [L = 2-carboxy-1,10-phenanthroline] Chinese J. of Struct. Chem., 2008, 27, 610-615.
　　YU Ming-Ming, ZHAO Xi-Juan, FU Wen-Fu Synthesis, Structure and Luminescent Properties of Polymeric Copper(I) Halide Complexes Bearing Phosphine and N-donor Bridging Ligands Chinese J. of Struct. Chem., 2007, 26, 1179-1183.
　　Zhan-Xian Li, Wen-Fu Fu , Ming-Ming Yu, Xi-Juan Zhao, Yong Chen The synthesis and properties of phenolic schiff bases based on 1,8-naphthyridine Dyes and Pigments, 2007, 75, 516–520.
　　Zhan Xian LI, Mei Gong FAN, Wen Fu FU, Ming Ming YU, Xi Juan ZHAO, De Hui WANG Synthesis of New O?N?C Ligands Chin. Chem. Lett., 2006, 17(8), 1017-1020.

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯誤或者偏差，歡迎隨時與我們聯(lián)系，以便進(jìn)行更新完善。
 

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