中國藥科大學(xué)藥學(xué)院導(dǎo)師：錢海 正文

　　錢海 博士，副教授
　　2001年畢業(yè)于山東大學(xué)藥學(xué)院藥學(xué)專業(yè)，2007 獲中國藥科大學(xué)藥物化學(xué)專業(yè)博士學(xué)位。現(xiàn)任職藥學(xué)院新藥研究中心，主要從事藥物化學(xué)教學(xué)與新藥的設(shè)計合成及構(gòu)效關(guān)系研究。2010年獲第13屆中國藥學(xué)會-施維雅青年藥物化學(xué)獎。

　　研究方向：
　　心腦血管藥物及多肽藥物的設(shè)計合成及生物活性研究。

　　科研項目：
　　現(xiàn)主持教育部科學(xué)技術(shù)研究重點項目和教育部博士點研究項目各一項，參與國家“十一五”新藥創(chuàng)制重大專項臨床前和候選藥物各一項，承擔(dān)企業(yè)橫向課題一項。

　　近期代表論著：
　　現(xiàn)已發(fā)表論文14篇（SCI收錄 13篇），申請專利 8 項（授權(quán)4項）。
　　1. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhu, Jing Han, Wenlong Huang*, Hai Qian*. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. European Journal of Medicinal Chemistry， 2011,46 (7), 2901–2907.
　　2. Zhi-hong Zou, Xiao-bu Lan, Hai Qian*, Wen-long Huang*, Yun-man Li. Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.  Bioorganic & Medicinal Chemistry Letters，2011 , 21 (19), 5934–5938.
　　3. Bin Wang, Jing Li, Wen Long Huang*, Hui Bin Zhang, Hai Qian*, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents . Chinese Chemical Letters，2011, 22 (7),781–784.
　　4. Liang Ge, jingjie Wang, Xiaoyan Zhang, Huibin Zhang, Hai Qian*, Wenlong Huang and Jinpei Zhou*. Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs. Letters in Drug Design & Discovery, 2011, 8(1), 76-81.
　　5. Jinpei Zhou, Shuaijian Ni, Huibin Zhang, Hai Qian*, Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein & Peptide Letters, 2010, 17 (10), 1290-1295.
　　6. Hai Qian, Zhixian Fu, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Liang Ge*, Rui Lin, Haiyan Lin and Xiaowen Hu. Synthesis and Preliminary Biological Evaluation of Capsaicin Derivatives as Potential Analgesic Drugs. Medicinal Chemistry, 2010, 6(4), 205-210.
　　7. Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin and Dongyan Dai. Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery, 2010, 7(4), 235-237.
　　8. Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang*, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters. 2010, 21(4), 388-390.
　　9. Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin, Wei Chen and Dongyan Dai. Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery, 2010, 7(2), 122-127.
　　10. Jian Feng Ji , Hui Bin Zhang, Wen Long Huang*, Hai Qian*, Jin Pei Zhou. A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors. Chinese Chemical Letters, 2010, 21 (1), 67-69.
　　11. Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian*, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro- benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009, 6(8), 623-628.
　　12. Jinpei Zhou, Huibin Zhang, Hai Qian*, Liang Lin, Wenlong Huang* and Shuaijian Ni. Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery, 2009, 6(3), 181-185.
　　13. 錢海,黃文龍,饒光玲,葛亮,吳曉明.香蕉皮中3-甲基-7, 8-二羥基異色滿酮-4的含量測定.中國藥科大學(xué)學(xué)報. 2009, 40(6): 524-526.
　　14. Qian, Hai; Huang, WenLong; Wu, XiaoMing; Zhang, HuiBing; Zhou, JinPei; Ye, WenCai, A new isochroman- 4-one derivative from the peel of Musa sapientum L. and its total synthesis. Chinese Chemical Letters, 2007, 18, (10), 1227-1230.

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯誤或者偏差，歡迎隨時與我們聯(lián)系，以便進行更新完善。

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